![]() ![]() This hyperexcitability phenotype is variable and appears to be manifest in approximately 30% of BACE1 -/- mice. In addition, we find that kainic acid injection induces seizures of greater severity in BACE1 -/- mice relative to BACE1 +/+ littermates, and causes excitotoxic cell death in a subset of BACE1 -/- mice. ![]() We find that electroencephalographic recordings reveal epileptiform abnormalities in some BACE1 -/- mice, occasionally including generalized tonic-clonic and absence seizures. Here we report a seizure-susceptibility phenotype that we have identified and characterized in BACE1 -/- mice. ![]() Examination of BACE1 -/- mice can provide insight into this function and also help anticipate consequences of BACE1 inhibition. While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown. BACE1 is a key enzyme in the generation of the Aβ peptide that plays a central role in the pathogenesis of Alzheimer's disease. ![]()
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